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Targeted Allele Detail
Symbol: Casp12tm1Dwni
Name: caspase 12; targeted mutation 1, Donald W Nicholson
MGI ID: MGI:3832547
Gene: Casp12  Location: Chr9:5345430-5373032 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:144912
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA segment of exon 2 was targeted for replacement by a cassette consisting of the -galactosidase gene and the neomycin resistance gene, shifting the downstream sequence out of reading frame. Gene inactivation was confirmed by immunoblot analysis of protein extracts obtained from intestinal epithelial cells. Expression of the neighboring caspase genes Casp1 and Casp4 were unaffected in these mice. (J:144912)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp12 Mutation:  16 strains or lines available
Original:  J:144912 Saleh M, et al., Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature. 2006 Apr 20;440(7087):1064-8
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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