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Targeted Allele Detail
Symbol: Ldb3tm4Chen
Name: LIM domain binding 3; targeted mutation 4, Ju Chen
MGI ID: MGI:3832388
Synonyms: Cypherf
Gene: Ldb3  Location: Chr14:34526699-34588681 bp, - strand  Genetic Position: Chr14, 20.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:144739
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1 was flanked with loxP sites and an frt flanked neo cassette was inserted after the second loxP site via homologous recombination. The neo cassette was then removed by Flp mediated recombination. (J:144739)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldb3 Mutation:  11 strains or lines available
Original:  J:144739 Zheng M, et al., Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet. 2009 Feb 15;18(4):701-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory