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Targeted Allele Detail
Symbol: Nfatc1tm3Glm
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 3, Laurie H Glimcher
MGI ID: MGI:3831720
Synonyms: Nfatc1fl
Gene: Nfatc1  Location: Chr18:80606205-80713071 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:144598
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site replaced 3 kb of intronic sequence upstream of exon 3 and a floxed neomycin cassette replaced was placed downstream of the exon into a XbaI site. Mice derived from correctly targeted ES cells were crossed with EIIa-cre transgenic mice and progeny were selected by Southern blotting for selective loss of the neomycin resistance cassette. Protein expression was unaffected as determined by immunoblotting of splenocyte extracts. Cre-mediated excision of exon 3 will remove a regulatory domain necessary for proper protein function. (J:144598)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:  1 strain or line available
Original:  J:144598 Aliprantis AO, et al., NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008 Nov;118(11):3775-89
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory