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Hdac3tm1.2Eno
Targeted Allele Detail
Nomenclature
Symbol: Hdac3tm1.2Eno
Name: histone deacetylase 3; targeted mutation 1.2, Eric N Olson
MGI ID: MGI:3831694
Synonyms: Hdac3-
Gene: Hdac3  Location: Chr18:37935844-37954988 bp, - strand  Genetic Position: Chr18, 19.81 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted in intron 10 and an frt flanked neomycin selection as well as a second loxP site were placed in intron 14. Mice were then crossed to Tg(CAG-cre)13Miya transgenics resulting inb the excision of exons 11-14. (J:144604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac3 Mutation:  14 strains or lines available
References
Original:  J:144604 Montgomery RL, et al., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest. 2008 Nov;118(11):3588-97
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory