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Trafd1tm1Ayos
Targeted Allele Detail
Nomenclature
Symbol: Trafd1tm1Ayos
Name: TRAF type zinc finger domain containing 1; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3831676
Synonyms: FLN29-
Gene: Trafd1  Location: Chr5:121371725-121385632 bp, - strand  Genetic Position: Chr5, 61.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144594
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:144594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trafd1 Mutation:  16 strains or lines available
References
Original:  J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory