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Id1tm1Xhsu
Targeted Allele Detail
Nomenclature
Symbol: Id1tm1Xhsu
Name: inhibitor of DNA binding 1, HLH protein; targeted mutation 1, Xiao-Hong Sun
MGI ID: MGI:3831561
Synonyms: Id1GFP
Gene: Id1  Location: Chr2:152736251-152737410 bp, + strand  Genetic Position: Chr2, 75.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144696
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn eGFP vector and a floxed neomycin cassette was knocked into the untranslated region of exon 1 of the gene locus. Founder mice were crossed with EIIa-cre transgenic mice to remove the neomycin cassette, leaving behind a loxP site. GFP expression was detected in bone marrow cells of myeloid lineages in both heterozygote and homozygote mice. Endogenous protein was not detected in immunobloting of cytokine-stimulated bone marrow cells from homozygote mice confirming this is a null allele. (J:144696)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Id1 Mutation:  2 strains or lines available
References
Original:  J:144696 Perry SS, et al., Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance. Blood. 2007 Oct 1;110(7):2351-60
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory