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Targeted Allele Detail
Symbol: Ptentm1Rdp
Name: phosphatase and tensin homolog; targeted mutation 1, Ronald DePinho
MGI ID: MGI:3831201
Synonyms: PtenL, Ptenlox, Ptenlox5
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:140704
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:140704)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  36 strains or lines available
Original:  J:140704 Zheng H, et al., p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Oct 23;455(7216):1129-33
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory