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Foxa1tm1Khk
Targeted Allele Detail
Nomenclature
Symbol: Foxa1tm1Khk
Name: forkhead box A1; targeted mutation 1, Klaus H Kaestner
MGI ID: MGI:3831160
Synonyms: Foxa1flox, Foxa1loxP
Gene: Foxa1  Location: Chr12:57540631-57546121 bp, - strand  Genetic Position: Chr12, 24.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143476
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2, and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:143476)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxa1 Mutation:  1 strain or line available
References
Original:  J:143476 Gao N, et al., Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 2008 Dec 15;22(24):3435-48
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory