Foxa1^tm1Khk
Targeted Allele Detail

Summary

• Symbol: Foxa1^tm1Khk
• Name: forkhead box A1; targeted mutation 1, Klaus H Kaestner
• MGI ID: MGI:3831160
• Synonyms: Foxa1^flox, Foxa1^loxP
• Gene: Foxa1 Location: Chr12:57587414-57593702 bp, - strand Genetic Position: Chr12, 24.7 cM
• Alliance: Foxa1^tm1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143476
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:143476)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa1 Mutation: 20 strains or lines available

References

• Original: J:143476 Gao N, et al., Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 2008 Dec 15;22(24):3435-48
• All: 21 reference(s)