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Tgfbr1tm1Bopa
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr1tm1Bopa
Name: transforming growth factor, beta receptor I; targeted mutation 1, Boris Pasche
MGI ID: MGI:3831090
Gene: Tgfbr1  Location: Chr4:47353222-47414931 bp, + strand  Genetic Position: Chr4, 26.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143706
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.1 kb of genomic sequence in exon 1 following the translation initiation site was replaced with a neo cassette. The reduction in protein expression was confirmed by western blot analysis on tissues from heterozygous mice. (J:143706)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr1 Mutation:  16 strains or lines available
References
Original:  J:143706 Zeng Q, et al., Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. Cancer Res. 2009 Jan 15;69(2):678-86
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory