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En2tm6Alj
Targeted Allele Detail
Nomenclature
Symbol: En2tm6Alj
Name: engrailed 2; targeted mutation 6, Alexandra L Joyner
MGI ID: MGI:3831084
Synonyms: En2flox, En2lox
Gene: En2  Location: Chr5:28165694-28172166 bp, + strand  Genetic Position: Chr5, 13.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156169
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct contains a 3.1 kb En2 5' fragment, an Frt-flanked PGK-neo cassette followed by a LoxP site in the En2 intron and a 4.8 kb En2 genomic fragment containing a LoxP site in the XbaI site of the 3' UTR. Flpe-mediated recombination deleted the PGK-neo, producing an En2 allele with a floxed region. (J:156169)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  94 strains or lines available
References
Original:  J:156169 Cheng Y, et al., The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum. Development. 2010 Feb;137(3):519-29
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory