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Rims1tm3.1Sud
Targeted Allele Detail
Summary
Symbol: Rims1tm3.1Sud
Name: regulating synaptic membrane exocytosis 1; targeted mutation 3.1, Thomas C Sudhof
MGI ID: MGI:3830681
Synonyms: RIM1alphabeta-
Gene: Rims1  Location: Chr1:22356475-22845203 bp, - strand  Genetic Position: Chr1, 8.54 cM, cytoband A5
Alliance: Rims1tm3.1Sud page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143053
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 6 was removed by germ line, cre-mediated recombination. The absence of protein expression for both alpha and beta isoforms was confirmed by western blot analysis on brain extracts. (J:143053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rims1 Mutation:  87 strains or lines available
References
Original:  J:143053 Kaeser PS, et al., RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci. 2008 Dec 10;28(50):13435-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory