Slc1a3^{tm1(cre/ERT2)Mgoe}
Targeted Allele Detail

Summary

• Symbol: Slc1a3^{tm1(cre/ERT2)Mgoe}
• Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 1, Magdalena Goetz
• MGI ID: MGI:3830051
• Synonyms: GLAST-CreER, GLAST::CreERT2, GLAST::CreERT2/ZEG, Slc1a3^{tm1(cre/ERT2)Mgo}
• Gene: Slc1a3 Location: Chr15:8663608-8740248 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Slc1a3^{tm1(cre/ERT2)Mgoe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144088
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Slc1a3^{tm1(cre/ERT2)Mgoe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc1a3 (MGI:99917)

• Mutation details: A cre/ERT2 cassette was inserted, along with an Frt flanked PGK-neomycin selection cassette, into the EcoRI site in exon 2 66 bp upstream of the translation initiation site. Heterozygous mice were later crossed with Tg(ACTFLPe)9205Dym mice to excise the neomycin selection cassette. (J:144088)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc1a3 (mouse) Summary of all recombinase alleles driven by Slc1a3. Comparative matrix view of recombinase activities Alliance mouse Slc1a3 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc1a3 Mutation: 66 strains or lines available

References

• Original: J:144088 Mori T, et al., Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis. Glia. 2006 Jul;54(1):21-34
• All: 92 reference(s)