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Slc1a3tm1(cre/ERT2)Mgoe
Targeted Allele Detail
Nomenclature
Symbol: Slc1a3tm1(cre/ERT2)Mgoe
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 1, Magdalena Goetz
MGI ID: MGI:3830051
Synonyms: GLAST-CreER, GLAST::CreERT2, GLAST::CreERT2/ZEG, Slc1a3tm1(cre/ERT2)Mgo
Gene: Slc1a3  Location: Chr15:8663608-8740248 bp, - strand  Genetic Position: Chr15, 3.82 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144088
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA cre/ERT2 cassette was inserted, along with an Frt flanked PGK-neomycin selection cassette, into the EcoRI site in exon 2 66 bp upstream of the translation initiation site. Heterozygous mice were later crossed with Tg(ACTFLPe)9205Dym mice to excise the neomycin selection cassette. (J:144088)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc1a3 (mouse) Summary of all recombinase alleles driven by Slc1a3. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a3 Mutation:  51 strains or lines available
References
Original:  J:144088 Mori T, et al., Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis. Glia. 2006 Jul;54(1):21-34
All:  76 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory