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Il17ftm2Yiw
Targeted Allele Detail
Nomenclature
Symbol: Il17ftm2Yiw
Name: interleukin 17F; targeted mutation 2, Yoichiro Iwakura
MGI ID: MGI:3830038
Synonyms: IL-17F-
Gene: Il17f  Location: Chr1:20777146-20790617 bp, - strand  Genetic Position: Chr1, 6.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143719
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis gene locus lies within 60 kb of the highly homologous locus Il17A. In order to generate a double mutant, ES cells heterozygous for the Il17atm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in cis with the Il17atm1Yiw allele. Gene inactivation of both loci was confirmed by RT-PCR of activated splenocytes collected from homozygote mice. (J:143719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  11 strains or lines available
References
Original:  J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory