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Crktm1Cur
Targeted Allele Detail
Nomenclature
Symbol: Crktm1Cur
Name: v-crk avian sarcoma virus CT10 oncogene homolog; targeted mutation 1, Tom Curran
MGI ID: MGI:3830007
Synonyms: Crkf
Gene: Crk  Location: Chr11:75679259-75706908 bp, + strand  Genetic Position: Chr11, 45.92 cM, cytoband A-D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143049
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted 5' to exon 1, and a loxP-flanked neomycin selection cassete was inserted 3' to exon 1. (J:111399)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crk Mutation:  17 strains or lines available
References
Original:  J:143049 Park TJ, et al., Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci. 2008 Dec 10;28(50):13551-62
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory