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Crkltm1Cur
Targeted Allele Detail
Nomenclature
Symbol: Crkltm1Cur
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Tom Curran
MGI ID: MGI:3830004
Synonyms: Crk-Lf
Gene: Crkl  Location: Chr16:17451987-17487434 bp, + strand  Genetic Position: Chr16, 10.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143049
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. (J:143049)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:  5 strains or lines available
References
Original:  J:143049 Park TJ, et al., Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci. 2008 Dec 10;28(50):13551-62
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory