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Targeted Allele Detail
Symbol: Myo18btm1Jyo
Name: myosin XVIIIb; targeted mutation 1, Jun Yokota
MGI ID: MGI:3829997
Gene: Myo18b  Location: Chr5:112688876-112896362 bp, - strand  Genetic Position: Chr5, 54.8 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:142442
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA construct containing an nls-LacZ cassette and neo cassette was inserted in exon 2 after the translation initiation codon via homologous recombination. Western blot analysis of whole embryo lysates confirmed the absence of protein expression in homozygotes. LacZ expression is similar to endogenous gene expression. (J:142442)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myo18b Mutation:  2 strains or lines available
Original:  J:142442 Ajima R, et al., Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Genes Cells. 2008 Oct;13(10):987-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory