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Ncor2tm1Rev
Targeted Allele Detail
Nomenclature
Symbol: Ncor2tm1Rev
Name: nuclear receptor co-repressor 2; targeted mutation 1, Ronald M Evans
MGI ID: MGI:3829987
Synonyms: SMRTmRID, SMRTmRID1
Gene: Ncor2  Location: Chr5:125017153-125179219 bp, - strand  Genetic Position: Chr5, 63.96 cM, cytoband F
Defective bone growth in Ncor2tm1Rev/Ncor2tm1Rev mice

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142665
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsThis allele contains alanine mutations in the RID1 and RID2 domains that interrupt binding to nuclear hormone receptors. (J:142665)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncor2 Mutation:  133 strains or lines available
References
Original:  J:142665 Nofsinger RR, et al., SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):20021-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/05/2018
MGI 6.12
The Jackson Laboratory