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Flcntm1Btt
Targeted Allele Detail
Summary
Symbol: Flcntm1Btt
Name: folliculin; targeted mutation 1, Bin Tean Teh
MGI ID: MGI:3829641
Synonyms: BHDflox
Gene: Flcn  Location: Chr11:59682234-59700842 bp, - strand  Genetic Position: Chr11, 37.79 cM
Alliance: Flcntm1Btt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3 and 4 were flanked by loxP sites and an frt flanked neo cassette was inserted after the second loxP site via homologous recombination. The neo cassette was subsequently removed via Flp mediated recombination. (J:143922)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flcn Mutation:  40 strains or lines available
References
Original:  J:143922 Chen J, et al., Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One. 2008;3(10):e3581
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory