Tg(Cyp1a1-cre/ERT)1Dwi
Transgene Detail

Summary

• Symbol: Tg(Cyp1a1-cre/ERT)1Dwi
• Name: transgene insertion 1, Douglas J Winton
• MGI ID: MGI:3829429
• Synonyms: AhCreER, AhcreER^T, AhcreER^TM, Tg(Cyp1a1-cre/ESR1)1Dwi
• Transgene: Tg(Cyp1a1-cre/ERT)1Dwi Location: unknown
• Alliance: Tg(Cyp1a1-cre/ERT)1Dwi page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen and beta-naphthoflavone
• Mutation: Insertion
• Tg(Cyp1a1-cre/ERT)1Dwi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Cyp1a1 (24296)

  Cyp1a1

  (MGI:88588)

• Mutation details: The rat Cyp1a1 promoter was used to drive the expression of a cre/ERT fusion that is inducible and dose-dependent. Cre expression in various tissues (small intestine, liver, bladder, stomach, esophagus, and gall bladder) is only achieved following treatment with tamoxifen and beta-naphthoflavone. Two lines were created with identical expression patterns. (J:143936)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp1a1 (rat) Summary of all recombinase alleles driven by Cyp1a1. Comparative matrix view of recombinase activities Alliance rat Cyp1a1 gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cyp1a1-cre/ERT)1Dwi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143936 Kemp R, et al., Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity. Nucleic Acids Res. 2004;32(11):e92
• All: 29 reference(s)