Dock1^tm1Jfco
Targeted Allele Detail

Summary

• Symbol: Dock1^tm1Jfco
• Name: dedicator of cytokinesis 1; targeted mutation 1, Jean-Francois Cote
• MGI ID: MGI:3828065
• Gene: Dock1 Location: Chr7:134272416-134775376 bp, + strand Genetic Position: Chr7, 79.14 cM
• Alliance: Dock1^tm1Jfco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. The absence of protein expression was confirmed by western blot analysis. (J:143342)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock1 Mutation: 129 strains or lines available

References

• Original: J:143342 Laurin M, et al., The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15446-51
• All: 2 reference(s)