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Rhohtm1Brak
Targeted Allele Detail
Nomenclature
Symbol: Rhohtm1Brak
Name: ras homolog gene family, member H; targeted mutation 1, Cord Brakebusch
MGI ID: MGI:3826431
Synonyms: RhoH-
Gene: Rhoh  Location: Chr5:65863569-65896700 bp, + strand  Genetic Position: Chr5, 33.8 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143161
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.9 kb fragment encoding the first 42 amino acids was replaced with a neomycin resistance cassette. This removes the translation start site and the switch 1 region. Northern blot analysis indicated that no normal protein was expressed. (J:143161)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhoh Mutation:  1 strain or line available
References
Original:  J:143161 Dorn T, et al., RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood. 2007 Mar 15;109(6):2346-55
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory