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Targeted Allele Detail
Symbol: Ezh2tm2Sho
Name: enhancer of zeste homolog 2 (Drosophila); targeted mutation 2, Stuart Orkin
MGI ID: MGI:3823217
Synonyms: Ezh2fl
Gene: Ezh2  Location: Chr6:47530274-47595341 bp, - strand  Genetic Position: Chr6, 22.92 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:142193
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted into intron 13 and an additional loxP site was inserted into intron 15. Transient cre expression was used to remove the neo cassette in ES cells leaving exons 13 and 14 floxed. (J:142193)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ezh2 Mutation:  26 strains or lines available
Original:  J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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