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Fgfr3tm2Schl
Targeted Allele Detail
Nomenclature
Symbol: Fgfr3tm2Schl
Name: fibroblast growth factor receptor 3; targeted mutation 2, Joseph Schlessinger
MGI ID: MGI:3823026
Synonyms: Fgfr3c-
Gene: Fgfr3  Location: Chr5:33721724-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Morphological analysis of Fgfr3tm1Schl/Fgfr3tm1Schl and Fgfr3tm2Schl/Fgfr3tm2Schl mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142946
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin expression cassette was inserted into intron 9 and a stop codon was inserted in exon 9. This results in an incomplete and misfolded D3 segment in the mesenchymal or c isoform. Chimeric mice were mated to Tg(ACTB-cre)2Mrt mice to excise the floxed neo cassette. (J:142946)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  10 strains or lines available
References
Original:  J:142946 Eswarakumar VP, et al., Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3937-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory