Il15ra^tm1Wjl
Targeted Allele Detail

Summary

• Symbol: Il15ra^tm1Wjl
• Name: interleukin 15 receptor, alpha chain; targeted mutation 1, Warren J Leonard
• MGI ID: MGI:3822486
• Synonyms: IL-15Ralpha^ext/IL-2Ralpha^int
• Gene: Il15ra Location: Chr2:11709992-11738796 bp, + strand Genetic Position: Chr2, 8.97 cM
• Alliance: Il15ra^tm1Wjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replace with one containing sequence encoding for 13 amino acids of the Il2ra intracellular domain followed by a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. This allele encodes a fusion product containing the extracellular domain of Il15ra and the intracellular domain of Il2ra. (J:142570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15ra Mutation: 39 strains or lines available

References

• Original: J:142570 Wu Z, et al., The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Blood. 2008 Dec 1;112(12):4411-9
• All: 1 reference(s)