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Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
Transgene Detail
Nomenclature
Symbol: Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
Name: transgene insertion 1, Jeffrey Robbins
MGI ID: MGI:3822129
Synonyms: CAGCAT-Q79R-Shp2
Transgene: Tg(CAG-cat,-Ptpn11*Q97R)1Rbns  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns expresses 1 gene
 
Mutation detailsThe ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of arginine for glutamine at position 79, following removal of an intervening floxed chloramphenicol (cat) gene. The amino acid substitution results in an increase in phosphatase activity. Three lines were created and line 1 was used in subsequent experiments. (J:142212)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:142212 Krenz M, et al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18930-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory