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Snap25tm1.1Bark
Targeted Allele Detail
Nomenclature
Symbol: Snap25tm1.1Bark
Name: synaptosomal-associated protein 25; targeted mutation 1.1, Christina Bark
MGI ID: MGI:3821974
Gene: Snap25  Location: Chr2:136713453-136782428 bp, + strand  Genetic Position: Chr2, 67.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142096
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5b was replaced with the sequence for an additional exon5a. A floxed cre cassette used for selection purposes was inserted into intron 5 and removed by germ line, cre mediated recombination. The lack of B isoform mRNA was confirmed by semi-quantitative PCR while the overall protein expression level from this gene was slightly increased as determined by protein quantitation. (J:142096)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snap25 Mutation:  15 strains or lines available
References
Original:  J:142096 Johansson JU, et al., An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet. 2008 Nov;4(11):e1000278
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory