About   Help   FAQ
Transgene Detail
Symbol: Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis
Name: transgene insertion 35-1, Yuji Mishina
MGI ID: MGI:3821884
Synonyms: CAG-Z-EGFP-caAlk2
Transgene: Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis expresses 1 gene
Mutation detailsThe modified chicken beta-actin promoter (CAG) was used to drive ubiquitous expression of a floxed LacZ gene with a triple polyadenylation sequence followed by a constitutively active human ACVR1 sequence with the amino acid substitution of aspartic acid for glutamine at position 207 (Q207D), an IRES sequence, and the EGFP coding sequence. Five lines were established and expression analysis for one line (line 35-1) confirmed general, but not ubiquitous, expression of LacZ and cre-dependent general expression of the modified ACVR1 and EGFP. (J:109498)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:109498 Fukuda T, et al., Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis. 2006 Apr;44(4):159-67
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory