Bhlha15^{tm3(cre/ERT2)Skz}
Targeted Allele Detail

Summary

• Symbol: Bhlha15^{tm3(cre/ERT2)Skz}
• Name: basic helix-loop-helix family, member a15; targeted mutation 3, Stephen F Konieczny
• MGI ID: MGI:3821734
• Synonyms: Bhlha15^{tm3(cre/ESR1)Skz}, Mist1^creERT, Mist1^CreERT2, Mist1-CreERT2
• Gene: Bhlha15 Location: Chr5:144127104-144131259 bp, + strand Genetic Position: Chr5, 83.05 cM, cytoband G2-G3
• Alliance: Bhlha15^{tm3(cre/ERT2)Skz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142189
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Bhlha15^{tm3(cre/ERT2)Skz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Bhlha15 (MGI:891976)

• Mutation details: The entire coding region was replaced with a cre-ESR1 (ERT2) fusion to allow for inducible cre expression in acinar cells. (J:142189)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bhlha15 (mouse) Summary of all recombinase alleles driven by Bhlha15. Comparative matrix view of recombinase activities Alliance mouse Bhlha15 gene page

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bhlha15^{tm3(cre/ERT2)Skz}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bhlha15 Mutation: 15 strains or lines available

References

• Original: J:142189 Habbe N, et al., Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8
• All: 41 reference(s)