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Dlgap5tm1Tfts
Targeted Allele Detail
Nomenclature
Symbol: Dlgap5tm1Tfts
Name: discs, large (Drosophila) homolog-associated protein 5; targeted mutation 1, Ting-Fen Tsai
MGI ID: MGI:3821727
Synonyms: Hurp-
Gene: Dlgap5  Location: Chr14:47387779-47418407 bp, - strand  Genetic Position: Chr14, 24.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142315
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette followed by a 4.47 kb genomic DNA fragment containing parts of exons 2 and 4 and all of exon 3 was inserted. Northern blot analysis confirmed the absence of mRNA expression in homozygous mice. (J:142315)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dlgap5 Mutation:  23 strains or lines available
References
Original:  J:142315 Tsai CY, et al., Hurp deficiency in mice leads to female infertility caused by an implantation defect. J Biol Chem. 2008 Sep 26;283(39):26302-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory