About   Help   FAQ
Targeted Allele Detail
Symbol: Myh11tm2Peri
Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 2, Muthu Periasamy
MGI ID: MGI:3821724
Synonyms: SM2-
Gene: Myh11  Location: Chr16:14194527-14291408 bp, - strand  Genetic Position: Chr16, 9.71 cM
Myh11tm2Peri/Myh11tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:142230
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 41 was replaced with a neo cassette. The absence of isoform SM2 and reduced presence of isoform SM1 was confirmed by western blot analysis on bladder extracts. (J:142230)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:  4 strains or lines available
Original:  J:142230 Chi M, et al., Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18614-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory