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Targeted Allele Detail
Symbol: Pak6tm1Amin
Name: p21 (RAC1) activated kinase 6; targeted mutation 1, Audrey Minden
MGI ID: MGI:3821622
Gene: Pak6  Location: Chr2:118663303-118698020 bp, + strand  Genetic Position: Chr2, 59.41 cM
Germline Transmission:  Earliest citation of germline transmission: J:141962
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll of exon 1 and part of exon 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:141962)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pak6 Mutation:  16 strains or lines available
Original:  J:141962 Nekrasova T, et al., Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008 Oct 1;322(1):95-108
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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