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Zbtb7btm1.2Litt
Targeted Allele Detail
Nomenclature
Symbol: Zbtb7btm1.2Litt
Name: zinc finger and BTB domain containing 7B; targeted mutation 1.2, Dan R Littman
MGI ID: MGI:3821621
Synonyms: ThPOK-
Gene: Zbtb7b  Location: Chr3:89377644-89394776 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141144
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMice carrying the Zbtb7btm1Litt allele were crossed with a cre transgenic strain to remove the entire coding sequence of the gene locus from germline cells, leaving behind a single loxP site. No protein expression was detected in immunoblot analysis of thymocytes. (J:141144)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  14 strains or lines available
References
Original:  J:141144 Egawa T, et al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory