About   Help   FAQ
Zbtb7btm1.2Litt
Targeted Allele Detail
Nomenclature
Symbol: Zbtb7btm1.2Litt
Name: zinc finger and BTB domain containing 7B; targeted mutation 1.2, Dan R Littman
MGI ID: MGI:3821621
Synonyms: ThPOK-
Gene: Zbtb7b  Location: Chr3:89377644-89393673 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141144
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMice carrying the Zbtb7btm1Litt allele were crossed with a cre transgenic strain to remove the entire coding sequence of the gene locus from germline cells, leaving behind a single loxP site. No protein expression was detected in immunoblot analysis of thymocytes. (J:141144)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  19 strains or lines available
References
Original:  J:141144 Egawa T, et al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory