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Chemically induced Allele Detail
Symbol: Hbb-b1MommeD7
Name: hemoglobin, beta adult major chain; modifier of murine metastable epialleles, D7
MGI ID: MGI:3821597
Synonyms: RBC14
Gene: Hbb-b1  Location: unknown  Genetic Position: Chr7, 54.85 cM
Strain of Origin:  FVB/N
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU induced a T to C substitution at position 757 in the mRNA altering the canonical polyadenylation signal. Northern blot analysis on RNA from fetal liver cells from homozygous and heterozygous mice detected reduced expression of the wild-type transcript and the presence of larger RNA species not seen in wild-type samples. (J:190446)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-b1 Mutation:  3 strains or lines available
Original:  J:142335 Ashe A, et al., A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol. 2008 Dec 19;9(12):R182
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory