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Selltm3Tft
Targeted Allele Detail
Nomenclature
Symbol: Selltm3Tft
Name: selectin, lymphocyte; targeted mutation 3, Thomas F Tedder
MGI ID: MGI:3820623
Synonyms: Ldelta
Gene: Sell  Location: Chr1:164061982-164084181 bp, + strand  Genetic Position: Chr1, 71.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142184
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe membrane-proximal region encoding a TNRSFSKIK motif was removed by homologous recombination leaving the rest of the coding sequence in-frame. A floxed neomycin cassette was included for targeting purposes downstream from the transmembrane encoding region. Mice homozygous for this mutation do not express protein on the cell surface of lymphocytes. (J:142184)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sell Mutation:  23 strains or lines available
References
Original:  J:142184 Venturi GM, et al., Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003 Nov;19(5):713-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory