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Oprm1tm1Jabl
Targeted Allele Detail
Nomenclature
Symbol: Oprm1tm1Jabl
Name: opioid receptor, mu 1; targeted mutation 1, Julie A Blendy
MGI ID: MGI:3820121
Synonyms: MOPRA112G, Oprm1A112G, Oprm1A112GJabl
Gene: Oprm1  Location: Chr10:6758593-7038209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150840
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsAn A to G point mutation at position 112 was created in a BAC harboring exon 1, which corresponds to the SNP position 118 in the human sequence, and changes codon 38 from asparigine to aspartic acid (N38D). A second mutation (T108C) was introduced to abolish a BstXI restriction site without affecting the aspartic acid encoded by the codon. A floxed neomycin cassette was inserted downstream of the targeted exon and was later removed by crossing founder mice with cre transgenic mice. Protein expression in the thalamus of homozygote mice was reduced compared to mice carrying the wild-type allele. (J:150840)
Generation of the Oprm1tm1Jabl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  35 strains or lines available
References
Original:  J:150840 Mague SD, et al., Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10847-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory