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Targeted Allele Detail
Symbol: Aiptm1Bra
Name: aryl-hydrocarbon receptor-interacting protein; targeted mutation 1, Christopher A Bradfield
MGI ID: MGI:3819941
Synonyms: Ara9-, Ara9deltaCfx
Gene: Aip  Location: Chr19:4114446-4125858 bp, - strand  Genetic Position: Chr19, 3.82 cM
Vessel caliber is decreased in Aiptm1Bra/Aiptm1Bra fetuses

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:141575
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Inversion
  Aiptm1Bra involves 1 genes/genome features (Aip) View all
Mutation detailsExons 3-6 were flanked by loxP sites and were inverted to an antisense orientation via homologous recombination (Aiptm2.1Bra ). This reverses the sequence of the C-terminal tetratricopeptide repeats and should result in the truncation of the protein. A neomycin cassette was also inserted following exon 6 and flanked on either side with Frt sites. The neomycin cassette was removed by mating with FLPeR mice (Gt(ROSA)26Sortm1(FLP1)Dym). (J:141575)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aip Mutation:  8 strains or lines available
Original:  J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory