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Targeted Allele Detail
Symbol: Smad4tm2.1Rob
Name: SMAD family member 4; targeted mutation 2.1, Elizabeth J Robertson
MGI ID: MGI:3819836
Synonyms: Smad4deltaNES
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:141589
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed PGK-hygro cassette was inserted into intron 3 and an additional loxP site was inserted into intron 4. Exon 4 and the selection cassette were removed either by transient cre expression in ES cells or by crossing chimeric mice containing the Smad4 allele to Tg(Sox2-cre)1Amc mice. (J:141589)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  13 strains or lines available
Original:  J:141589 Biondi CA, et al., Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J. 2007 Jun 1;404(2):235-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory