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Nalcntm1.1Dren
Targeted Allele Detail
Nomenclature
Symbol: Nalcntm1.1Dren
Name: sodium leak channel, non-selective; targeted mutation 1.1, Dejian Ren
MGI ID: MGI:3819820
Gene: Nalcn  Location: Chr14:123276641-123627144 bp, - strand  Genetic Position: Chr14, 66.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141581
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove exon 1. The absence of transcript expression was confirmed by semi-quantitative RT-PCR on E18.5 brain extracts. (J:141581)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nalcn Mutation:  53 strains or lines available
References
Original:  J:141581 Lu B, et al., The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 2007 Apr 20;129(2):371-83
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory