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Targeted Allele Detail
Symbol: Txniptm1Rlee
Name: thioredoxin interacting protein; targeted mutation 1, Richard T Lee
MGI ID: MGI:3818743
Synonyms: Txnipflox
Gene: Txnip  Location: Chr3:96465273-96469173 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Germline Transmission:  Earliest citation of germline transmission: J:141487
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted 168 bp upstream of the first ATG codon in exon 1 and an frt flanked neo cassette and second loxP were inserted downstream of exon 1 via homologous recombination. The neo cassette was removed via in vivo flp-mediated recombination. (J:141487)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:  40 strains or lines available
Original:  J:141487 Yoshioka J, et al., Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 7;101(12):1328-38
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory