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Tg(Ins-Igf2)1Fbos
Transgene Detail
Nomenclature
Symbol: Tg(Ins-Igf2)1Fbos
Name: transgene insertion 1, Fatima Bosch
MGI ID: MGI:3818739
Synonyms: RIPI/IGF-II
Transgene: Tg(Ins-Igf2)1Fbos  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins-Igf2)1Fbos expresses 1 gene
 
Mutation detailsThe rat promoter was used to drive islet-specific expression of the mouse gene. Three lines were created (lines 1, 2 and 3) with similar phenotype. Line 1 was chosen as the representative line and has 40 copies of the transgene. (J:141527)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Calcific Aortic Valve Disease J:227165 in mice homozygous for Apobtm2Sgy and Ldlrtm1Her and carrying the Tg(Ins-Igf2)1Fbos transgene.
References
Original:  J:141527 Devedjian JC, et al., Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. J Clin Invest. 2000 Mar;105(6):731-40
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory