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Targeted Allele Detail
Symbol: Hgstm2Tkh
Name: HGF-regulated tyrosine kinase substrate; targeted mutation 2, Nobuyuki Tanaka
MGI ID: MGI:3818694
Synonyms: hrsloxP
Gene: Hgs  Location: Chr11:120467635-120483979 bp, + strand  Genetic Position: Chr11, 84.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:141391
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:141391)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hgs Mutation:  24 strains or lines available
Original:  J:141391 Tamai K, et al., Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am J Pathol. 2008 Dec;173(6):1806-17
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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