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Spontaneous Allele Detail
Symbol: Coro1aptcd
Name: coronin, actin binding protein 1A; peripheral T cell deficiency
MGI ID: MGI:3818503
Synonyms: Coro1AE26K, ptcd
Gene: Coro1a  Location: Chr7:126699773-126707787 bp, - strand  Genetic Position: Chr7, 69.25 cM, cytoband F3
Strain of Origin:  CTS
Allele Type:    Spontaneous
Mutations:    Nucleotide substitutions, Single point mutation
Mutation detailsG-to-A spontaneous mutation in exon 2 of the gene locus resulted in a non-conservative glutamic acid-to-lysine substitution at residue 26 in the beta-propeller domain of the protein. This residue was in a surface-exposed loop12 adjacent to a region that in the related protein Coro1B has been indicated to be an actin-binding site. The mutant protein was found to not localize to the leading edge of migrating T cells in the manner that the endogenous protein does. Immunoblot analysis showed that the abundance of the mutant protein in homozygote thymocytes was similar to the endogenous protein in wild-type controls. (J:141431)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Coro1a Mutation:  3 strains or lines available
This mutation arose spontaneously in the inbred CTS mouse strain that also carries the Cts allele associated with cataracts and microphthalmia.

Original:  J:45972 Kimura S, et al., Genetic control of peripheral T-cell deficiency in the cataract Shionogi (CTS) mouse linked to chromosome 7. Immunogenetics. 1998;47(3):278-80
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory