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Targeted Allele Detail
Symbol: Atg16l1tm1Aki
Name: autophagy related 16-like 1 (S. cerevisiae); targeted mutation 1, Shizuo Akira
MGI ID: MGI:3818483
Synonyms: Atg16L1delta
Gene: Atg16l1  Location: Chr1:87756006-87792428 bp, + strand  Genetic Position: Chr1, 44.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:141420
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3, 4 and 5 that encode the coiled-coiled domain of the gene product were replaced with a neomycin resistance cassette. Immunoblotting of homozygote embryonic fibroblast lysate indicated two truncated proteins were produced. Ectopic expression of similar truncated proteins in wild-type embryonic fibroblasts indicated that the truncated proteins do not interfere in a dominant negative manner with autophagy processes. (J:141420)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atg16l1 Mutation:  7 strains or lines available
Original:  J:141420 Saitoh T, et al., Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008 Nov 13;456(7219):264-8
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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