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Rorctm3Litt
Targeted Allele Detail
Nomenclature
Symbol: Rorctm3Litt
Name: RAR-related orphan receptor gamma; targeted mutation 3, Dan R Littman
MGI ID: MGI:3818459
Synonyms: RORgammaflox
Gene: Rorc  Location: Chr3:94372794-94398276 bp, + strand  Genetic Position: Chr3, 40.56 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229446
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3-6 of the targeted gene are flanked by loxP sites. A floxed neomycin resistance gene used in the construction of this strain was deleted by partial recombination. (J:229446)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rorc Mutation:  31 strains or lines available
References
Original:  J:229446 Choi GB, et al., The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26;351(6276):933-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory