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Gene trapped Allele Detail
Symbol: Tdp1Gt(XD105)Byg
Name: tyrosyl-DNA phosphodiesterase 1; gene trap XD105, BayGenomics
MGI ID: MGI:3818340
Gene: Tdp1  Location: Chr12:99884517-99955219 bp, + strand  Genetic Position: Chr12, 50.43 cM
Mutant Cell Line:  XD105 (BayGenomics)
Germline Transmission:  Earliest citation of germline transmission: J:127602
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
Mutation detailsA gene trap vector containing a beta-geo cassette was inserted downstream of exon 10. The absence of protein expression was confirmed by western blot analysis on cortex, cerbellum and spleen extracts. (J:127605)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
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View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tdp1 Mutation:  29 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Original:  J:127605 Katyal S, et al., TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J. 2007 Nov 14;26(22):4720-31
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory