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Ccm2tm1.1Kwhi
Targeted Allele Detail
Nomenclature
Symbol: Ccm2tm1.1Kwhi
Name: cerebral cavernous malformation 2; targeted mutation 1.1, Kevin Whitehead
MGI ID: MGI:3817970
Gene: Ccm2  Location: Chr11:6546887-6596744 bp, + strand  Genetic Position: Chr11, 4.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146527
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsMice carrying the Ccm2tm1Kwhi allele that has exons 3-10 floxed were crossed with Hprttm1(cre)Mnn. Removal of the floxed exons from the germline was confirmed by genomic PCR on the offspring. This is considered a null allele. (J:146527)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccm2 Mutation:  39 strains or lines available
References
Original:  J:146527 Whitehead KJ, et al., The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009 Feb;15(2):177-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory