About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Ccm2tm1Kwhi
Targeted Allele Detail
Nomenclature
Symbol: Ccm2tm1Kwhi
Name: cerebral cavernous malformation 2; targeted mutation 1, Kevin Whitehead
MGI ID: MGI:3817969
Gene: Ccm2  Location: Chr11:6546887-6596744 bp, + strand  Genetic Position: Chr11, 4.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146527
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and a neomycin resistance cassette followed by a loxP site and then an EGFP gene were all inserted downstream of the last exon (exon 10). Correct targeting was confirmed by genomic PCR. (J:146527)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccm2 Mutation:  39 strains or lines available
References
Original:  J:146527 Whitehead KJ, et al., The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009 Feb;15(2):177-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory